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Unless you’re going for a specific effect, or are pairing panels like the previous point states, keep your gutters the same size throughout your pages. There’s little confusion as to where the reader should look next. The divide between tiers is extremely clear, making it very obvious which panels are associated with each other.
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These pages from Dragon Ball Z express the point well (though you could probably get away with a more subtle approach). By increasing the size of the gutter in between panels, you can split up a page into sections of grouped panels. When reading something, the eye naturally wants to jump to nearby panels before going to ones that are further away. Remember, a large part of page composition is about guiding the eye to the correct next panel.
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Your first focus when designing a page should be it’s composition: how the panels fit together on the page. Power through Composition (video) - Strip Panel Naked Panel Layout: The Golden Ratio (article) - Making Comics Really, really cool.Īdvanced Layouts: Paneling Outside the Box (article) - Aaron Diaz Comic Book Paper (webapp) - You pick the number of panels in your page and it provides a whole bunch of sample page layouts.